Cloning. chromosomal localization and expression pattern of the POU domain gene Oct-11
- 1 January 1993
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 21 (1) , 127-134
- https://doi.org/10.1093/nar/21.1.127
Abstract
POU domain genes encode a family of highly conserved transacting factors that influence the transcriptional activity of several cell type-specific and ubiquitous genes. We have cloned and sequenced cDNAs encoding a novel mouse POU domain protein, Oct-11, that is closely related within the POU domain to the POU class II proteins, Oct-1 and Oct-2. Recombinant Oct-11 protein binds specifically to an octamer sequence in vitro. The Oct-11 gene is expressed during mouse embryogenesis and in the adult thymus and testis. In addition, it is abundant in the myeloma cell line P3/NS-1/1-Ag4.1. We describe the structure of Oct-11 and its chromosomal localization, and discuss the evidence that the POU class II gene family has evolved by duplication and divergence of a common ancestral gene.Keywords
This publication has 61 references indexed in Scilit:
- Chromosomal location of the octamer transcription factors, Otf-1, Otf-2, and Otf-3, defines multiple Otf-3-related sequences dispersed in the mouse genomeGenomics, 1991
- Use of bacteriophage T7 lysozyme to improve an inducible T7 expression systemJournal of Molecular Biology, 1991
- Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis.The Journal of Experimental Medicine, 1990
- A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryoNature, 1990
- The gene for the ubiquitous octamer-binding protein Oct-1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1Genomics, 1990
- New type of POU domain in germ line-specific protein Oct-4Nature, 1990
- Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA MotifScience, 1988
- At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cellsJournal of Molecular Biology, 1987
- Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomasNature, 1983
- Intracellular immunoglobulin chain synthesis in non-secreting variants of a mouse myeloma: Detection of inactive light-chain messenger RNAJournal of Molecular Biology, 1974