Nutritional dose of magnesium in hypertensive patients on beta blockers lowers systolic blood pressure: a double‐blind, cross‐over study
- 3 August 1994
- journal article
- clinical trial
- Published by Wiley in Journal of Internal Medicine
- Vol. 236 (2) , 189-195
- https://doi.org/10.1111/j.1365-2796.1994.tb01282.x
Abstract
To evaluate if magnesium alters blood pressure in hypertensive patients treated with beta blockers and if such effect can be coupled to a change in potassium and magnesium levels in muscle, serum and urine. A randomized double-blind, cross-over study with magnesium and placebo taken orally, each for 8 weeks. Outpatient clinic, University Hospital, Umeå, Sweden. Thirty-nine patients aged 26-69 years with moderate essential hypertension, treated before entry and during the study with continuous, unchanged beta blockers completed the study. Random allocation to receive magnesium aspartate or placebo. Daily magnesium dose was 15 mmol (365 mg) distributed three times a day over 8 weeks. Blood pressure, serum, urine and muscle magnesium and potassium. Measurements performed at the start, after 8 and 16 weeks. Systolic supine and standing blood pressure significantly decreased when magnesium was supplemented following placebo but not when magnesium was given at start. When magnesium and placebo groups were independently compared there was no significant change in supine and standing systolic and diastolic pressure. Serum and urine magnesium and serum potassium were significantly higher after magnesium treatment, whilst no change was present in urine potassium or in muscle magnesium and potassium. This study showed that 15 mmol magnesium day-1 given to mild to moderate hypertensive patients treated with beta blockers could be the cause of a significant decrease in supine and standing systolic blood pressure.Keywords
This publication has 12 references indexed in Scilit:
- The Dose-Dependent Reduction in Blood Pressure Through Administration of Magnesium A Double Blind Placebo Controlled Cross-Over StudyAmerican Journal of Hypertension, 1993
- Blood Pressure Response During Long-Term Treatment With Magnesium Is Dependent on Magnesium StatusAmerican Journal of Hypertension, 1991
- Magnesium ions in cardiac functionBiochemical Pharmacology, 1989
- Adrenergic control of plasma magnesium in manClinical Science, 1987
- Lack of effect of oral magnesium on high blood pressure: a double blind study.BMJ, 1985
- Divalent Cations in Essential HypertensionNew England Journal of Medicine, 1983
- Effect of magnesium on blood pressure.BMJ, 1983
- Hypomagnesemia and hypokalemia in 1,000 treated ambulatory hypertensive patients.Journal of the American College of Nutrition, 1982
- Hypokalaemia and diuretics: an analysis of publications.BMJ, 1980