Abstract
This article reports the development of a eukaryotic protein database (Clusters of Orthologous Groups [termed KOGs]) at NCBI for 7 eukaryotic genomes and updating of the prokaryotic counterpart (COGs database), which now includes 63 sequenced genomes. The basic KOG relationships were determined using best reciprocal hits with Blast and analyzed for domain structures, providing for two additional categories: "fuzzy" orthologous...

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