CYTOCHEMICAL STUDY OF PERITONEAL-MACROPHAGES IN CARRAGEENAN-TREATED IMMUNOSUPPRESSED MICE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 50  (5) , 435-442
Abstract
The cytochemical characters of the peritoneal macrophages of immunosuppressed mice (Is-PM) were studied. The acid phosphatase activity of their lysosomal system decreased in comparison to control cells (N-PM). In Is-PM cells the polyanion content of the cell-coat and the expression of their Con [concanavalin] A receptors decreased, the glycos- and galactosaminoglycan (GAG) content showed a decrease on the surface of every cell of the population. On the 1st day following carrageenan treatment, acid phosphatase activity of the cells was very low; the GAG content and the Con A receptors of the cell-coat disappeared. The characteristic lysosomal alterations were still observed on the 6th day after treatment. Treatment with carrageenan apparently impaired the lysosomal system of macrophages and the cell surface. These cytochemical changes may explain the dramatic decrease in macrophage function observed in carageenan treatment.

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