CARBOHYDRATE‐INDUCED LIPOGENESIS IN THE HUMANPLACENTA OF NORMAL AND DIABETIC PREGNANCIES
- 1 June 1975
- journal article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 82 (6) , 471-475
- https://doi.org/10.1111/j.1471-0528.1975.tb00672.x
Abstract
Using in vitro incubation, human placental slices have been shown to synthesize lipid from 14-C fructose, but to a lesser extent than from 14-C glucose. Diabetic placentae did not incorporate more of either sugar into lipid than did placentae from normal pregnancies; nor did insulin in the incubation medium enhance lipogenesis. There was a correlation between the extent of incorporation of 14-C fructose and 14-C glucose into triglyceride, suggesting a linked enzyme system for phosphorylation of the two hexoses.Keywords
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