Massive cutaneous hyalinosis. A newly recognized disease

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Abstract
A disease characterized by massive tumorous cutaneous hyalinosis was studied histologically, immunologically and biochemically. The precipitated hyalin material differed from amyloid in being Congo-red-negative and ultrastructurally nonfibrillary. In lipoid proteinosis, massive hyalin deposits were not encountered and the clinical course was distinct from the course of massive cutaneous hyalinosis. The clinical and histologic pictures of adult and juvenile forms of colloid milium differed from that found in the patient, although the colloid milium in adult form was ultrastructurally also nonfibrillary like the hyalin from the patient. A strong humoral immune response to components of the cytoskeleton of fibroblasts and especially to keratin was found in the patient.