CNS influence on plasma levels of factor 8 activity

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Abstract
Permanent electrodes were implanted in various subcortical areas in 12 dogs. During the following year short periods of electrical stimulation were delivered to these brain sites. Areas associated with an increase in plasma factor VHI (antihemophilic) activity included the reticular formation, lateral hypothalamic area, mesencephalic central gray, and the habenula and habenula-interpeduncular tract. Decreases in factor VIII activity followed stimulation of the hippocampus, some lateral hypothalamic areas, the mamillary nuclei, and their related projection systems. All these areas are thought to participate in autonomic integrative functions. No associated change in hematocrit, prothrombin, or profibrinolytic activity was seen. The changes in factor VHI activity were transient and usually returned to base line at the end of 1 hr. These studies suggest that discrete CNS [central nervous system] mechanisms exist which assist in the integrative regulation of plasma levels of factor VQI activity.