OBSERVATIONS ON REMYELINATION IN THE RABBIT SPINAL CORD FOLLOWING DEMYELINATION INDUCED BY LYSOLECITHIN
- 1 January 1978
- journal article
- research article
- Published by Wiley in Neuropathology and Applied Neurobiology
- Vol. 4 (1) , 47-59
- https://doi.org/10.1111/j.1365-2990.1978.tb00528.x
Abstract
The extent and type of remyelination that occurred following demyelination induced by intraspinal injection of small volumes of lysolecithin was examined in 24 rabbits. Unlike the rat and cat following this procedure remyelination is not complete even after 6 months' survival and little Schwann cell invasion occurs. The cellular environment around remyelinated and persistently demyelinated axons differed. Remyelination was associated with a good astrocytic presence and removal of myelin debris, while persistently demyelinated axons were surrounded by myelin debris and a poor astrocytic presence. It was concluded that the environment around the demyelinated axon influences oligodendrocyte remyelination.This publication has 16 references indexed in Scilit:
- Regeneration of Oligodendroglia During Recovery from Demyelinating DiseaseScience, 1977
- THE EFFECTS OF MITOMYCIN C ON THE PROCESS OF REGENERATION IN THE MAMMALIAN PERIPHERAL NERVOUS SYSTEMNeuropathology and Applied Neurobiology, 1977
- Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve I. Cell proliferationJournal of Comparative Neurology, 1976
- INVASION OF SCHWANN CELLS INTO THE SPINAL CORD OF THE RAT FOLLOWING LOCAL INJECTIONS OF LYSOLECITHINNeuropathology and Applied Neurobiology, 1976
- Remyelination by Schwann cells of axons demyelinated by intraspinal injection of 6-aminonicotinamide in the ratJournal of Neurocytology, 1975
- THE EFFECTS OF MITOMYCIN C ON THE PROCESS OF REMYELINATION IN THE MAMMALIAN PERIPHERAL NERVOUS SYSTEMNeuropathology and Applied Neurobiology, 1975
- Regeneration and remyelination ofXenopus tadpole optic nerve fibres following transection or crushJournal of Neurocytology, 1974
- Pattern of remyelination in the CNSNature, 1974
- ELECTRON MICROSCOPIC FEATURES OF MULTIPLE SCLEROSIS LESIONSBrain, 1965
- The relationship between enzyme activity and neuroglia in plaques of multiple sclerosisJournal of Neurology, Neurosurgery & Psychiatry, 1963