Liposome‐mediated delivery stimulates a class I‐restricted cytotoxic T cell response to soluble antigen
- 1 January 1992
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 22 (1) , 287-290
- https://doi.org/10.1002/eji.1830220143
Abstract
Most soluble protein antigens are poor at priming class I-restricted cytotoxic cell activity. In this study we show that incorporation of one protein, ovalbumin, into liposomes converts this antigen into an effective stimulator of antigen-specific cytotoxicity. The mechanisms responsible for this phenomenon are discussed.Keywords
This publication has 17 references indexed in Scilit:
- Immunological adjuvants: a role for liposomesImmunology Today, 1990
- In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccineNature, 1989
- Antigen Recognition by Class I-Restricted T LymphocytesAnnual Review of Immunology, 1989
- Introduction of soluble protein into the class I pathway of antigen processing and presentationCell, 1988
- Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides.The Journal of Experimental Medicine, 1988
- A synthetic peptide induces long-term protection from lethal infection with herpes simplex virus 2.The Journal of Experimental Medicine, 1987
- Therapy with monoclonal antibodies by elimination of T-cell subsets in vivoNature, 1984
- The Complete Amino‐Acid Sequence of Hen OvalbuminEuropean Journal of Biochemistry, 1981
- Synthetic phospholipid vesicles containing a purified viral antigen and cell membrane proteins stimulate the development of cytotoxic T lymphocytes.The Journal of Experimental Medicine, 1979
- Hepatitis B surface antigen‐containing liposomes enhance humoral and cell‐mediated immunity to the antigenFEBS Letters, 1979