Analysis ofMoraxella catarrhalisouter membrane antigens cross-reactive withNeisseria meningitidisandNeisseria lactamica
Open Access
- 1 January 2004
- journal article
- Published by Oxford University Press (OUP) in FEMS Immunology & Medical Microbiology
- Vol. 40 (1) , 89-94
- https://doi.org/10.1016/s0928-8244(03)00298-0
Abstract
Mouse sera against outer membrane proteins from Moraxella catarrhalis, Neisseria meningitidis and Neisseria lactamica, and human sera from both healthy individuals and patients convalescing from meningococcal meningitis were used to identify cross-reactive antigens. Mouse anti-N. meningitidis and anti-N. lactamica sera recognized 77, 62 and 32 kDa outer membrane antigens in M. catarrhalis strains; on the contrary, the meningococcal porin PorB (38–42 kDa) was recognized by one of the two anti-M. catarrhalis sera. Human sera from both healthy individuals and patients convalescing from meningococcal meningitis also showed cross-reactive antibodies against these proteins. The existence of cross-reactive antigens in M. catarrhalis and N. meningitidis (as well as in N. lactamica) could favor the development of natural immunization against both pathogens.Keywords
This publication has 17 references indexed in Scilit:
- Analysis ofNeisseria lactamicaantigens putatively implicated in acquisition of natural immunity toNeisseria meningitidisFEMS Immunology & Medical Microbiology, 2002
- In vitro induction of memory-driven responses against Neisseria meningitidis by priming with Neisseria lactamicaVaccine, 2002
- Neisseria lactamica Protects against Experimental Meningococcal InfectionInfection and Immunity, 2002
- The nasopharyngeal bacterial flora in infancy: effects of age, gender, season, viral upper respiratory tract infection and sleeping positionFEMS Immunology & Medical Microbiology, 1999
- Bactericidal activity of antibodies elicited against the Neisseria meningitidis 37-kDa ferric binding protein (FbpA) with different adjuvantsFEMS Immunology & Medical Microbiology, 1998
- Middle ear mucin glycoprotein: Purification and interaction with nontypable andOtolaryngology -- Head and Neck Surgery, 1997
- Identification and characterization of specific sequences encoding pathogenicity associated proteins in the genome of commensalNeisseriaspeciesFEMS Microbiology Letters, 1995
- Molecular cloning and characterization of outer membrane protein E of Moraxella (Branhamella) catarrhalisJournal of Bacteriology, 1994
- The interaction between human transferrin and transferrin binding protein 2 from Moraxella (Branhamella) catarrhalis differs from that of other human pathogensMicrobial Pathogenesis, 1993
- HUMAN IMMUNITY TO THE MENINGOCOCCUSThe Journal of Experimental Medicine, 1969