Cooperation of signalling pathways in embryonic mammary gland development
- 1 December 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 8 (12) , 963-972
- https://doi.org/10.1038/nrg2227
Abstract
Mammary glands become functional only in adult life but their development starts in the embryo. Initiation of the epithelial bud and ductal outgrowth are coordinated through short-range signals between epithelium and mesenchyme. Studies of natural and induced mouse mutants in which early mammary development is perturbed have identified genetic networks that regulate specific steps in these processes. Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer.Keywords
This publication has 50 references indexed in Scilit:
- Signalling Pathways Implicated in Early Mammary Gland Morphogenesis and Breast CancerPLoS Genetics, 2006
- Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specificationGenes & Development, 2005
- Identification of signaling pathways in early mammary gland development by mouse geneticsBreast Cancer Research, 2004
- Stimulation of ectodermal organ development by Ectodysplasin-A1Developmental Biology, 2003
- Regulation of Tbx3 Expression by Anteroposterior Signalling in Vertebrate Limb DevelopmentDevelopmental Biology, 2002
- Mammary gland patterning in the AXB/BXA recombinant inbred strains of mouseMechanisms of Development, 2000
- The characterization of a mouse mutant that displays abnormal mammary gland development.Mammalian Genome, 2000
- Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasiaNature Genetics, 1999
- Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndromeNature Genetics, 1997
- X–linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane proteinNature Genetics, 1996