Expression of CXCR4 Predicts Poor Prognosis in Patients with Malignant Melanoma
Open Access
- 1 March 2005
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 11 (5) , 1835-1841
- https://doi.org/10.1158/1078-0432.ccr-04-1887
Abstract
Purpose: CXCR4 receptor and its unique ligand, the CXCL12 chemokine, have been recently implicated in cancer metastasis. Evidence about the role of CXCR4/CXCL12 axis has been reported in several cancers including melanoma. Our goal was to investigate if CXCR4 expression has a prognostic value in malignant melanoma.Keywords
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