Biosynthetic origins of the oxygen atoms in the ansamycin antibiotics rifamycin B, O, and S
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 5,p. 311-313
- https://doi.org/10.1039/c39890000311
Abstract
Cultures of Nocardia mediterrance utilise atmospheric oxygen to form the C-1 oxygen function and C-29 vinyl ether group of the ansamycin antibiotics rifamycin B, O, and S, while the C-8 phenolic hydroxy group and C-8 carbon atom are both derived from the carboxy group of 3-amino-5-hydroxybenzoic acid; these results exclude 8-deoxyansamycins as possible biosynthetic intermediates.Keywords
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