Prevention of T Cell Anergy by Signaling Through the γ c Chain of the IL-2 Receptor
- 11 November 1994
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 266 (5187) , 1039-1042
- https://doi.org/10.1126/science.7973657
Abstract
When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness, termed anergy. In this study, signaling through the common γ chain of the interleukin-2 (IL-2), IL-4, and IL-7 receptors in the presence of antigen was found to be sufficient to prevent the induction of anergy. After culture with IL-2, IL-4, or IL-7, Jak3 kinase was tyrosine-phosphorylated, which correlated with the prevention of anergy. Therefore, a signal through the common γ chain may regulate the decision of T cells to either clonally expand or enter a state of anergy.Keywords
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