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Abstract
In rabbits, the immunoglobulin allotypes b4, b5, b6 and b9 are associated with antigenic determinants on light polypeptide chains (2). Genes which behave as alleles at the “b locus” appear to control at least part of the amino acid sequence of these antigenically distinct forms of light chains. It is possible that the “b locus” actually represents a genetic region consisting of several closely linked and related cistrons. However, to date no one has detected production of more than two of the four known “b locus allotypes” in an individual rabbit. On the other hand, the c7 allotype (originally designated “P” (3)) is detectable in the sera of numerous rabbits, no matter whether they are heterozygous or homozygous at the a and b loci (3, 4). The c7 antigenic determinants are detected with specific isoantisera on molecules which have the immunoelectrophoretic characteristics of rabbit IgG.

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