Transmission of Infectious Mononucleosis by Transfusion of Pre-Illness Plasma

Abstract
The transmission of infectious mononucleosis by transfusion of platelet-rich plasma is reported. Seventeen days after the donation of the plasma to his leukemic brother, the donor developed clinical signs of infectious mononucleosis. The disease manifested itself in the leukemic brother 30 days after he received the plasma, at which time specific heterophile antibodies were noted, as well as Epstein-Barr virus antibody seroconversion. The infectivity of pre-illness plasma in infectious mononucleosis is suggested.

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