MAMMARY-TUMORS INDUCED IN RATS BY ADRIAMYCIN AND DAUNOMYCIN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (5) , 1444-1446
Abstract
The 2 anthracycline antitumor antibiotics, adriamycin and daunomycin (DM), induced a high incidence of mammary tumors, fibroadenomas and adenocarcinomas, in female rats that received a single i.v. dose, thus confirming previous results. The incidence of DM-induced adenocarcinomas increased with the dose of the drug, whereas the incidence of adriamycin-induced adenocarcinomas showed a plateau at 5 mg/kg and above. Adriamycin- and DM-induced fibroadenomas showed a peak at lower doses (about 5-6 mg/kg). With the highest DM dose (12.5 mg/kg) used, there was a slight prevalence of adenocarcinomas over fibroadenomas.

This publication has 0 references indexed in Scilit: