Coriadienin, the First Annonaceous Acetogenin with Two Double Bonds Isolated from Annona coriaceae
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 59 (5) , 528-530
- https://doi.org/10.1021/np960079e
Abstract
A new Annonaceous acetogenin, coriadienin (1), has been isolated from the roots of Annona coriacea Mart. (Annonaceae). This structure is the first reported acetogenin containing two double bonds. Compound 1 showed potent cytotoxicity against VERO and KB cell lines. Compound 1 appears to play an important role in the biosynthetic pathway of mono- and bis-THF acetogenins, and it is proposed as a biogenetic precursor of coriacin. A known cytotoxic acetogenin, gigantetronenin, was also isolated from this plant.Keywords
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