A General Approach to the Synthesis of Bisindolylmaleimides: Synthesis of Staurosporine Aglycone
- 31 December 1995
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1995 (12) , 1511-1516
- https://doi.org/10.1055/s-1995-4146
Abstract
Bisindolylmaleimides are prepared in 65-95% yield by reaction of an indole Grignard with either 2,3-dichloro-N-methylmaleimide or 2,3-dichloromaleimide. A one-step synthesis of arcyriarubin A in 72% yield affords ready access to the staurosporine aglycone.Keywords
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