Ascorbate-quinone interactions: electrochemical, free radical, and cytotoxic properties.
- 1 January 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (1) , 129-132
- https://doi.org/10.1073/pnas.80.1.129
Abstract
Standard midpoint potentials were determined for p-benzoquinone, methoxy-p-benzoquinone and 2,3-, 2,5- and 2,6-dimethoxy-p-benzoquinones in aqueous solution. ESR studies were made of the ascorbate and semiquinone radicals produced when these quinones interact with sodium ascorbate. Direct correlations are found between the electrochemical potentials, generated semiquinone lifetimes and cytotoxic action in Ehrlich ascites [mouse tumor cells]-bearing mice. [The cytotoxic action of quinone anticancer drugs may be mediated through their semiquinone free radical metabolites resulting from 1-electron redox reactions.].This publication has 5 references indexed in Scilit:
- Water structure-dependent charge transport in proteins.Proceedings of the National Academy of Sciences, 1981
- GENERAL MECHANISM FOR MICROSOMAL ACTIVATION OF QUINONE ANTI-CANCER AGENTS TO FREE-RADICALS1978
- Electronic properties of the casein-methylglyoxal complex.Proceedings of the National Academy of Sciences, 1977
- Electron Paramagnetic Resonance of Undissociated p-BenzosemiquinonesJournal of the American Chemical Society, 1965
- 940. Fermentation products of wheat germ. (a) Identification of methoxy- and 2 : 6-dimethoxy-p-benzoquinone. (b) Infra-red absorption of some quinones and 1 : 2-dicarbonyl compoundsJournal of the Chemical Society, 1951