Debridement of Experimental Burns With Clostridium histolyticum H-4 Enzymes*

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Abstract
A series of experiments is reported in which the possibility of applying skin grafts to recipient areas left by debridement of full thickness burns with Clostridium histolyticum H-4 enzymes was tested in guinea pigs. These enzymes did not de-bride these burns satisfactorily for this purpose, and other experiments suggest that they damage normal muscular tissue sufficiently to prevent it from accepting skin grafts. These experiments reemphasize the points that the results of in vitro experiments may not be extrapolated to in vivo experiments and that results obtained from animal experiments may not be applicable to humans.