A monoclonal antibody specific for equine trophoblast

Publisher Website
Google Scholar
Abstract
Summary: A monoclonal antibody specific for horse trophoblast was produced after immunisation of mice with isolated chorionic girdle cells. When tested using an indirect immunoperoxidase assay, this antibody (F102.1) labelled both the non‐invasive trophoblast of the allantochorion and the invasive trophoblast of the chorionic girdle, as well as the mature endometrial cup cells which secrete equine chorionic gonadotrophin. Antibody F102.1 failed to label any of 18 adult and 6 foetal horse tissues, or any cells in the foetus or placenta with the exception of the trophoblast. Longitudinal studies demonstrated that the molecule identified by antibody F102.1 is expressed between Day 12 and term. There is no evidence that the molecule recognised by antibody F102.1 is antigenic in pregnancy, and no function has yet been ascribed to the molecule.