Progressive Structural Brain Abnormalities and Their Relationship to Clinical Outcome
Top Cited Papers
Open Access
- 1 June 2003
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 60 (6) , 585-594
- https://doi.org/10.1001/archpsyc.60.6.585
Abstract
IN VIVO neuroimaging has provided compelling evidence for structural1-3 and functional4,5 brain abnormalities in schizophrenia. Findings of enlarged lateral ventricles, third ventricles, and cortical sulcal cerebrospinal fluid (CSF) spaces; reductions in medial temporal lobe structures and frontal lobes; and abnormalities in subcortical structures have been replicated fairly consistently in many magnetic resonance imaging (MRI) studies.3 However, except for the association between poor outcome and enlarged lateral ventricles, the significance of the other commonly replicated brain abnormalities on functional outcome in schizophrenia remains uncertain.6 Furthermore, the onset and longitudinal evolution of these anomalies during the course of schizophrenia have not been well characterized.Keywords
This publication has 1 reference indexed in Scilit:
- Implications of Normal Brain Development for the Pathogenesis of SchizophreniaArchives of General Psychiatry, 1987