cAMP response element modulator (CREM): an essential factor for spermatogenesis in primates?

Open Access

1 June 2001

journal article
review article
Published by Wiley in International Journal of Andrology

Vol. 24 (3) , 126-135
https://doi.org/10.1046/j.1365-2605.2001.00277.x

Abstract

CREM is a cAMP‐related transcription factor and alternate promotor usage and splicing generate repressor and activator transcripts of CREM within the testis. CREM activators are highly expressed in post‐meiotic haploid germ cells and are essential for spermatid maturation in the mouse model as revealed by gene‐targeting studies. Analysis of testicular CREM expression in rodent and monkey species, and in men yielded a highly comparable pattern thus suggesting that CREM is of general importance for spermatid development in the mammalian testis. Also, many CREM target genes have been identified in haploid germ cells. Studies in men with spermatogenic disturbance and spermatid maturation arrest demonstrated abnormal CREM expression and altered splicing events. Collectively, the data strongly argue for an essential role of CREM during spermatid maturation in primates.

Keywords

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