Comparison of Superparamagnetic Iron Oxide–Enhanced and Gadobenate Dimeglumine–Enhanced Dynamic MRI for Detection of Small Hepatocellular Carcinomas

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Abstract
OBJECTIVE. The purpose of this study was to compare superparamagnetic iron oxide (SPIO)–enhanced MRI with gadobenate dimeglumine–enhanced MRI for the detection of hepatocellular carcinoma using receiver operating characteristic (ROC) analysis.MATERIALS AND METHODS. Twenty-nine consecutive patients with 35 hepatocellular carcinomas underwent gadobenate dimeglumine–enhanced MRI (unenhanced, arterial, portal, and equilibrium phases) using 3D fat-saturated volumetric interpolated imaging and SPIO-enhanced MRI on a 1.5-T unit. SPIO-enhanced T2-weighted turbo spin-echo and T2*-weighted gradient-echo sequences were performed 48 hr after completion of the dynamic study. Three observers independently interpreted the images in random order, separately, and without patient identifiers. Diagnostic accuracy was evaluated using the alternative free response receiver operating characteristic method. Sensitivity and positive predictive value were also evaluated.RESULTS. The mean sensitivity and positive predictive value ...