In vitroAntigenotoxic Activity of Novel Ginseng Saponin Metabolites Formed by Intestinal Bacteria

1 August 1998

journal article
research article
Published by Georg Thieme Verlag KG in Planta Medica

Vol. 64 (06) , 500-503
https://doi.org/10.1055/s-2006-957501

Abstract

Ginseng saponin metabolites produced by human intestinal bacteria were evaluated for antigenotoxic properties by testing their effects on benzo[a]pyrene (B[a]P)-induced mutagenicity and clastogenicity. They include 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol (IH-901), 20-O-[α-D-arabinopyranosyl(1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol (IH-902) and 20-O-[α-D-arabinofuranosyl(1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol (IH-903). IH-901, IH-902 and IH-903 inhibited the mutagenicity of B[a]P in a dose-dependent manner. In the chromosome aberration assay, IH-901 and IH-903 reduced the frequency of chromosome aberration induced by B[a]P. These results suggest that the ginseng saponin metabolites tested in the present study have potential as chemopreventive agents.

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