Combination of antidepressant drugs: the case of inositol
- 26 January 2001
- journal article
- research article
- Published by Wiley in Human Psychopharmacology: Clinical and Experimental
- Vol. 16 (1) , 37-43
- https://doi.org/10.1002/hup.181
Abstract
Inositol is a second messenger precursor that is effective in depression and obsessive‐compulsive disorder via a mechanism different from serotonin reuptake inhibitors. However, controlled trials of inositol combined with serotonin reuptake inhibitors in depression or in reuptake inhibitor resistant depressed patients, or in partially responsive obsessive‐compulsive patients, did not reveal added benefit. This is comparable to results with combinations of other antidepressant treatments, such as tricyclics plus monoamine oxidase inhibitors. Copyright © 2001 John Wiley & Sons, Ltd.Keywords
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