Interactions between oxotremorine and inhibitors of Cholinesterase enzymes

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Abstract
Interactions between oxotremorine and physostigmine or dyflos have been investigated in mice using doses giving approximately 50% inhibition of mouse brain cholinesterase. Oxotremorine LD50 was unaffected by pretreatment of mice with the anticholinesterases. Its ED50 (tremor) was decreased by physostigmine and neostigmine but not by dyflos. Dyflos antagonized oxotremorine hypothermia, physostigmine was without effect. Oxotremorine did not alter the inhibitory activity of the anticholinesterases. The lack of potentiation of oxotremorine by cholinesterase inhibitors suggests it acts directly in these tests by a mechanism independent of its ability to increase tissue acetylcholine concentration.