Genetic Characteristics of Echovirus Type 9 Strains: Association of Mouse Virulence with Other Genetic Markers

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Abstract
SUMMARY In naturally occurring strains and laboratory selected variants of echovirus type 9, the association between virulence for infant mice (v) and the repro- ductive capacity at 4 °0 (t) was of the v+t + and v-t- types. By different selection methods the two other marker combinations, v+t - and v-t +, were obtained. The frequency of t ÷ in a t- echovirus type 9 population was IO -5. Of the four possible combinations between the v and c (cytopathic effect for human epithelial cell lines) markers, only three were found. The v+c + covariation could not be obtained in spite of appropriate methods of selection.

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