Tropical Splenomegaly Syndrome in Zambia: Further Observations and Effects of Cycloguanil and Proguanil
- 20 February 1971
- Vol. 1 (5746) , 429-432
- https://doi.org/10.1136/bmj.1.5746.429
Abstract
Nineteen Zambian patients with the tropical splenomegaly syndrome and sinusoidal lymphocytosis on liver biopsy were studied. The association of macrobulinaemia with the tropical splenomegaly syndrome has again been confirmed. Sixteen patients were treated with antimalarials—12 with cycloguanil pamoate alone, 3 with cycloguanil and proguanil, and 1 with proguanil alone. Twelve patients were observed for periods of sufficient length for the drug effect to be assessed, and in 11 there was a good response in terms of decrease in spleen size. Cycloguanil pamoate may be of value both for prophylaxis and treatment in areas where tropical splenomegaly syndrome is endemic.Keywords
This publication has 9 references indexed in Scilit:
- Clinical Trial of Malaria Prophylaxis in Tropical Splenomegaly SyndromeBMJ, 1971
- Tropical Splenomegaly Syndrome: Long-term Proguanil Therapy Correlated with Spleen Size, Serum IgM, and Lymphocyte TransformationBMJ, 1970
- A survey of the incidence of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency in ZambiaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1970
- Splenomegaly in the tropics.BMJ, 1969
- Idiopathic Tropical Splenomegaly Syndrome in IbadanBMJ, 1968
- Serial liver biopsies in big slpeen disease.1968
- The tropical splenomegaly syndromeTransactions of the Royal Society of Tropical Medicine and Hygiene, 1968
- SPLENOMEGALY IN NEW GUINEA1967
- Immunochemical quantitation of antigens by single radial immunodiffusionImmunochemistry, 1965