Angiotensinogen in Human Essential Hypertension
- 1 December 1996
- journal article
- review article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 28 (6) , 1123-1125
- https://doi.org/10.1161/01.hyp.28.6.1123
Abstract
The candidacy of angiotensinogen for a role in the genetic basis of hypertension is supported by the observation that plasma angiotensinogen levels track with raised blood pressure through families. In addition, transgenic mice with overexpression of a rat angiotensinogen gene develop hypertension, and knockout mice with a disrupted gene and absent angiotensinogen production develop low blood pressure. There are now two studies in populations of white European origin and one in African Caribbeans providing support for a role of the angiotensinogen gene locus in human essential hypertension.Keywords
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