THE EFFECT OF HYSTERECTOMY ON THE ACTION OF OESTRONE ON THE SYMPHYSIS PUBIS OF OVARIECTOMIZED MICE

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Abstract
The experiments described are part of an attempt to discover why, in the response of the mouse pelvis to oestrogens, the anterior border and dorsal aspect of the symphysis pubis are always affected first, and in particular whether the reproductive tract (part of which lies in close apposition to the dorsal surface of the symphysis) plays a role in the reaction. Ninety-one ovariectomized albino mice were used in five experiments. Oestrone in doses of 3–30 μg./day was injected subcutaneously for 8–24 days into animals with the reproductive tract intact, or from which uterine horns, or cervix, or cervix and vagina had been removed. The pelves were examined by means of X-ray photographs, macroscopically at autopsy, and by histological investigation. The results showed that the action of oestrone on the symphysis pubis is not affected by removal of the uterine horns, cervix or vagina, and it is therefore unlikely that these structures play any role in the reaction.