Mouse Testes as a Biological Test System for Intercomparison of Fast Neutron Therapy Beams

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Abstract
Testicular damage as measured by decreased incorporation of labeled tracers, testes weight or testes DNA content was investigated as a possible biological test system for intercomparing fast neutron therapy beams. Actual intercomparisons of neutrons produced by 16, 22, 35 and 50-MeV-deuteron bombardment of Be were made using mouse testes weight and DNA content as biological endpoints. Measurement of the white blood cell count in the same animals used for testes analysis was used to confirm the physical dosimetry. The results indicated that 16, 22 and 35 MeV deuteron beams were, respectively, 34, 21 and 12% more effective in producing testes damage as compared to the 50 MeV deuteron beam.

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