The effect of homozygous sickle cell disease on the age at menarche in Nigerian schoolgirls
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Annals of Human Biology
- Vol. 14 (2) , 181-185
- https://doi.org/10.1080/03014468700006902
Abstract
Two thousand two hundred and four schoolgirls from four secondary schools in Enugu, the capital of Anambra State in south-eastern Nigeria, were interviewed and provided information regarding their age, menstrual status and the presence or absence of some common chronic disorders. Sickle cell disease was identified and confirmed by haemoglobin electrophoresis in 1·36% of the students. Average age at menarche, determined by probit analysis, was significantly delayed among subjects with sickle cell disease when compared with normal students (14·5 ± 1·13 years vs. 13·3 ± 1·09 years; P < 0·005). Comparison of the average menarcheal age of the normal subjects in this study with previous reports of studies from southern Nigeria confirms a continuing decline of the average age at menarche at a rate of about four months per decade. Zweitausendzweihundertvier Schulmädchen aus vier Hauptschulen in Enugu, der Hauptstadt des Staates Anambra des südöstlichen Nigeria, wurden interviewt und lieferten Information bezüglich ihres Alters, Menstrualstatusses und der Anwesenheit oder Abwesenheit einiger verbreiteter chronischer Störungen. Die Sichelzell-Krankheit wurde bei 1, 36% der Schülerinnen identifiziert und durch Haemoglobin-Elektrophorese bestätigt. Das mittlere Menarchealter, bestimmt durch Probit-Analyse, war bei Probandinnen mit Sichelzell-Krankheit signifikant verzögert im Vergleich mit normalen Schülerinnen (14,5 ± 1,13 Jahre zu 13,3 ± 1,09 Jahre; P P <0,005). La comparaison de l'ăge médian de la ménarche chez les sujets normaux de cette étude avec les résultats précédemment obtenus dans cette région méridionale du Nigéria, confirme un abaissement régulier de cet ăge médian, à un rythme d'environ quatre mois par décennie.This publication has 15 references indexed in Scilit:
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