An in vivo complex with DNA photolyase blocks UV mutagenesis targeted at a thymine-cytosine dimer in Escherichia coli
Open Access
- 1 November 1988
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 170 (11) , 5371-5374
- https://doi.org/10.1128/jb.170.11.5371-5374.1988
Abstract
UV mutation frequency responses for two types of Escherichia coli prototrophic mutant were measured. Only the response associated with a mutation targeted by a thymine-cytosine pyrimidine dimer was reduced in the dark in cells with amplified DNA photolyase. This specific reduction is attributed to the interruption of mutational DNA synthesis by a photolyase complex at the targeting dimer.Keywords
This publication has 26 references indexed in Scilit:
- Effect of photoreactivation on mutagenesis of lambda phage by ultraviolet lightJournal of Molecular Biology, 1988
- UV mutagenesis in E. coli with excision repair initiated by uvrABC or denV gene productsMutation Research/DNA Repair Reports, 1988
- Current understanding of UV-induced base pair substitution mutation in E. coli with particular reference to the DNA polymerase III complexMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1987
- Structure and function of DNA photolyasesTrends in Biochemical Sciences, 1987
- Photoreactivation of UV damage in Escherichia coli uvrA6: Lethality is more effectively reversed than either premutagenic lesions or SOS inductionMutation Research/DNA Repair Reports, 1985
- Binding of Escherichia coli DNA photolyase to UV-irradiated DNABiochemistry, 1985
- UV-Mutagenesis at a cloned target sequence: Converted suppressor mutation is insensitive to mutation frequency decline regardless of the gene orientationMutation Research/DNA Repair Reports, 1984
- A multiply phr-plasmid increases the ultraviolet resistance of a recA strain of Escherichia coliMutation Research/DNA Repair Reports, 1984
- Misrepair of overlapping daughter strand gaps as a possible mechanism for UV induced mutagenesis in UVR strains of Escherchia coli: A general model for induced mutagenesis by misrepair (SOS repair) of closely spaced DNA lesionsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
- Analysis of photoenzymatic repair of UV lesions in DNA by single flashes IV. Mutations affecting the number of photoreactivating enzyme molecules in E. coli cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1969