THE ABILITY OF 17-ETHYL-19-NORTESTOSTERONE TO BLOCK ETHIONINE-INDUCED FATTY LIVER IN RATS

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Abstract
Lipid infiltration of the liver caused by ethionine treatment of the castrate rat can be effectively blocked by certain testosterone derivatives as exemplified by 17-ethyl-19-nortestosterone at a dose that does not stimulate growth of secondary sex organs. The protective action of such a substance does not depend on progesterone-like action but upon a property apparently associated with its myotrophic activity. This supports the hypothesis that the major defect imposed by ethionine administration is one in protein metabolism secondary to which may be the alteration in lipid metabolism that was studied here.