Otolaryngologic Aspects of Neurofibromatosis

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Abstract
Neurofibromatosis is a generalized disease with the potential for involvement of the temporal bone, oral cavity, upper respiratory tract, and soft tissues of the face and neck. The natural course of this disease and its diagnosis and complications are presented, and avenues of medical and surgical therapy are discussed. PRESENTATION OF CASE A 23-year-old man was admitted to the hospital of the University of Pennsylvania (the service of Steven D. Handler, MD) in October 1977 with the chief complaint of difficulty swallowing. Neurofibromatosis had been diagnosed clinically in 1965 and confirmed by biopsy in 1974. In January 1977, hoarseness developed, and a left vocal cord paralysis was discovered. In June 1977, the patient noted an enlarging, painless mass in the left supraclavicular area. Dysphagia also developed at that time and had caused a 7-kg weight loss. The patient was able to swallow only soft or finely ground food. The past

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