STUDIES ON WATER METABOLISM OF PYRIDOXINE AND PANTOTHENIC ACID DEFICIENT RATS

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Abstract
1. Rats maintained on a diet deficient in pyridoxine or in pantothenic acid exhibit a delayed diuretic response to a water load. 2. Pitressin evokes the same response in deficient rats as in well nourished controls. When pyridoxine or pantothenate deficient animals are injected with Pitressin, they excrete similar amounts of the hormone as do normal controls. Experiments carried out in vivo and in vitro showed that the ability of the liver to inactivate Pitressin is not impaired in these nutritional disorders. Thus Pitressin was found not to be involved in this derangement of water metabolism. 3. DOCA, cortisone and ACTH were found to be without any effect on the diuresis of normal hydrated rats. Animals suffering from lack of pyridoxine or pantothenic acid increased their urine excretion after injection of cortisone or ACTH. DOCA had no influence under these conditions.