Ethanol Specifically Potentiates GABA-Mediated Neurotransmission in Feline Cerebral Cortex
- 8 August 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4457) , 708-710
- https://doi.org/10.1126/science.7394531
Abstract
Ethanol (ethyl alcohol) potentiates the inhibition of cortical neurons by γ-aminobutyric acid. This effect is specific, since ethanol does not potentiate inhibition by glycine, serotonin, or dopamine. These results have implications for alcoholism because (i) γ-aminobutyric acid mediates anxiolytic mechanisms, and (ii) anxiety is implicated in the etiology of alcoholism.Keywords
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