Inhibition of LTB4 binding to human neutrophils by nordihydroguaiaretic acid
- 1 August 1987
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 21 (3-4) , 358-360
- https://doi.org/10.1007/bf01966515
Abstract
Nordihydroguaiaretic acid (NDGA) was investigated for its ability to interact with leukotriene B4 receptors on human polymorphonuclear leukocytes (hPMNs).3H-LTB4 binding to specific receptors was reduced in a dose-dependent manner with maximal reduction at 100 μM NDGA and an IC50 of about 50 μM. Binding of another inflammatory stimulus, N-formyl-norleucyl-leucyl-phenylalanine (FNLP) was not affected by similar treatment. Chemotaxis and enzyme release stimulated by LTB4 and oligopeptide were inhibited by NDGA. In addition, LTB4-triggered inflammationin vivo in mice was inhibited by systemic administration of NDGA. These data suggest that LTB4 receptor antagonism may contribute to inhibition of inflammation by NDGA.Keywords
This publication has 6 references indexed in Scilit:
- Leukotriene B4 binding to human neutrophilsProstaglandins, 1984
- Oxidation of leukotrienes at the omega end: demonstration of a receptor for the 20-hydroxy derivative of leukotriene B4 on human neutrophils and implications for the analysis of leukotriene receptors.Proceedings of the National Academy of Sciences, 1984
- Heterogeneity of human polymorphonuclear leukocyte receptors for leukotriene B4. Identification of a subset of high affinity receptors that transduce the chemotactic response.The Journal of Experimental Medicine, 1984
- Specific binding of leukotriene B4 to a receptor on human polymorphonuclear leukocytes.The Journal of Experimental Medicine, 1983
- Specific binding of leukotriene B4 to receptors on human polymorphonuclear leukocytes.The Journal of Immunology, 1982