Inactivation of Angiotensin II in Liver

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Abstract
1. Angiotensinase activity was the highest in the supernatant fraction among the liver cell subfractions from normal rabbits. 2. Comparison of angiotensinase activity in the supernatant fraction of liver cells and in plasma from a normal rabbit was made by means of horizontal starch block electrophoresis. The patterns from both sources were very similar, that is, the activity was demonstrated in the albumin zone. 3. The in vivo pressor response of angiotensin injected through the portal system was markedly reduced compared with that via the auricular vein or the femoral vein in normal rabbits. However, no significat difference between the pressor response of renin preparation via the portal vein and via the auricular vein was obtained.

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