The Ultrastructural Localization of Factor VIII‐Antigen in Human Platelets, Megakaryocytes and Endothelial Cells Utilizing a Ferritin‐labelled Antibody

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Abstract
By means of electron microscopy combined with the use of monospecific anti‐factor VIII‐antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.