The structural basis for the functional versatility of immunoglobulin G

1 December 1978

journal article
research article
Published by Canadian Science Publishing in Canadian Journal of Biochemistry

Vol. 56 (12) , 1087-1101
https://doi.org/10.1139/o78-172

Abstract

Current concepts of the structure of vertebrate immunoglobulin [Ig] G were reviewed. Contact residues in the antigen-combining site are contributed by the hypervariable regions of the H- and L-chains. Protein A of Staphylococcus aureus binds to IgG through a site formed by the C2 [2 chain constant region] and C3 domains of the Fc fragment.

This publication has 15 references indexed in Scilit:

Correlation between the exposure of aromatic chromophores at the surface of the Fc domains of immunoglobulin G and their ability to bind complement
Biochemistry, 1977
Immunoglobulin Binding by Mouse Intestinal Epithelial Cell Receptors
The Journal of Immunology, 1976
Covalent assembly of mouse immunoglobulin G subclasses in vitro: application of a theoretical model for interchain disulfide bond formation
Canadian Journal of Biochemistry, 1976
STRUCTURE AND FUNCTION OF IMMUNOGLOBULIN DOMAINS .5. BINDING OF IMMUNOGLOBULIN-G AND FRAGMENTS TO PLACENTAL MEMBRANE PREPARATIONS
1976
Crystallographic Structural Studies of a Human Fc Fragment. II. A Complete Model Based on a Fourier Map at 3.5 Å Resolution
Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1976
Properties of the Fc Receptor on Macrophages and Monocytes
Immunological Communications, 1976
BIOLOGIC ACTIVITIES OF AGGREGATED GAMMA-GLOBULIN .8. AGGREGATED IMMUNOGLOBULINS OF DIFFERENT CLASSES
1967
Heterogeneity in the Complementation of Polypeptide Subunits of a Purified Antibody Isolated from an Individual Rabbit
The Journal of Immunology, 1966
THE ROLE OF DISULFIDE BONDS IN THE COMPLEMENT-FIXING AND PRECIPITATING PROPERTIES OF 7S RABBIT AND SHEEP ANTIBODIES
The Journal of Experimental Medicine, 1964
The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain
Biochemical Journal, 1959