DNA Immunization withTrypanosoma cruziHSP70 Fused to the KMP11 Protein Elicits a Cytotoxic and Humoral Immune Response against the Antigen and Leads to Protection
Open Access
- 1 October 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (10) , 6558-6563
- https://doi.org/10.1128/iai.69.10.6558-6563.2001
Abstract
Murine immunization withTrypanosoma cruzi KMP11-HSP70fused genes but not theKMP11gene alone elicited both an immunoglobulin G2a long-lasting humoral immune response against KMP11 protein and activation of CD8+cytotoxic T lymphocytes specific for two KMP11 peptides containing A2 motifs. Moreover, protection against the parasite challenge was observed after immunization with the chimeric gene.Keywords
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