Effects of verapamil and BAY K8644 on the hypoxic contraction of the isolated human pulmonary artery.
- 1 January 1989
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 157 (1) , 81-82
- https://doi.org/10.1620/tjem.157.81
Abstract
To examine the effect of hypoxia on the human pulmonary artery (HPA), HPA segments (2 mm, o.d.) were suspended and changes in isometric force with hypoxia (PO2 = 44 .+-. 3 mmHg, mean .+-. S.E.) were measured. HPA contracted with hypoxia and the tension developed with 15 min of hypoxia was 127 .+-. 36 (mean .+-. S.E.) mg. Verapamil at 10-6 M inhibited and 10-6 M BAY K 8644 enhanced the hypoxic response by 47 .+-. 10% (p < 0.01) and 396 .+-. 106% (p < 0.05), respectively, compared with preceding values. These results show that activation of voltage-dependent Ca2+ channels also plays an important role in the mechanism of hypoxic pulmonary vasoconstriction in man.This publication has 3 references indexed in Scilit:
- Pulmonary vascular tone is increased by a voltage-dependent calcium channel potentiatorJournal of Applied Physiology, 1986
- Hypoxic induction of Ca2+-dependent action potentials in small pulmonary arteries of the catJournal of Applied Physiology, 1985
- Hypoxia-induced activation in small isolated pulmonary arteries from the catJournal of Applied Physiology, 1985