Effect of Menstruation on Serum CA125 Levels

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Abstract
CA125 levels were measured in the sera of 54 women with normal menstrual cycle and without infectious, benign and malignant gynecologic disorders. In 54 subjects studied, 13 (24%) had no significant variations in serum CA125 levels throughout the menstrual cycle. In contrast, there 41 (76%) had significant variations in serum CA125 with peak levels (51.8 +/- 6.5 U/ml, mean +/- SEM) during menstruation. The concentration reached a normal value (17.7 +/- 1.6 U/ml, mean +/- SEM) at proliferative phase, and remained low throughout the rest phases of the cycle. The mean peak level was significantly higher than that at proliferative phase (P < 0.001), where as no significant difference in mean concentration was detected between sequential phases from proliferative phase to premenstrual phase (P > 0.1). Among 41 with variable CA125 levels in the menstrual cycle, more than half of them, namely 39% of the total (21/54), had the levels of the upper limit or normal values.