Effect of Chloramphenicol and Thiamphenicol on the In Vitro Colony-forming Cell
Open Access
- 1 March 1974
- journal article
- Published by American Society of Hematology in Blood
- Vol. 43 (3) , 363-369
- https://doi.org/10.1182/blood.v43.3.363.363
Abstract
The effect of chloramphenicol and a chloramphenicol analog, thiamphenicol, on the growth of bone marrow colony-forming cells in agar was investigated. At concentrations within therapeutic range, both drugs cause a marked reduction in the number of colonies and in the size of aggregates, indicating suppressed cellular proliferation. The inhibition appears to be reversible within a 24-hr period of cell-drug contact. In addition to their effect on CFC proliferation, CAP and TAP appear to influence the type of CFC differentiation resulting in predominance of macrophage colonies.Keywords
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