Stimulatory effect of calcitonin on calcium excretion into bile of thyroparathyroidectomized rats.

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Abstract
The effect of calcitonin (CT) on the bile Ca excretion in thyroparathyroidectomized rats was investigated. A single i.p. injection of Ca (4.0 mg/100 g) markedly increased the bile Ca excretion of sham-operated rats, suggesting that an increase in serum Ca elevated the excretion of Ca into the bile. In thyroparathyroidectomized rats the injection of Ca did not significantly elevate the excretion of Ca into the bile. The bile Ca excretion of thyroparathyroidectomized rats injected with Ca was predominantly potentiated by the administration of CT. CT alone slightly increased the bile Ca excretion in thyroparathyroidectomized rats. In thyroparathyroidectomized rats injected with Ca, there was an increase in bile Ca excretion as early as 30 min after CT administration and the hormone markedly increased the bile Ca excretion even at the lowest dose (40 MRC [mouse radius calicifying units] mu/100 g). CT apparently stimulates the excretion of Ca into the bile through the liver when Ca increases in the serum.