Effects of Source Leukocyte Collection on the Immune System

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Abstract
To assess any immunologic effects that source leukocyte concentrate collection might have on double-bag plasmapheresis donors, several parameters were studied. Surveillance parameters, such as T vs. non-T lymphocyte subpopulations, showed no abnormal values in donors with as many as 500 visits over a 12-yr period. The frequency and the total number of leukocyte donations did not affect the lymphocyte subpopulations and functions observed. No significant changes were noted for specific and nonspecific stimulation, natural killer (NK) cell activity, lymphocyte surface markers and a variety of functional parameters. The apheresis donors manifested no differences in NK cell activity, human leukocyte interferon production, IgG synthesis by B cells and percent suppression of both IgG synthesis and mixed lymphocyte cultures, when compared to nonapheresed donors.