Drug‐induced inhibition of proteoglycanase activity in the hulth–telhag model

Publisher Website
Google Scholar
Abstract
Evidence has accumulated that there are increased degradative enzymes in osteoarthritis responsible for joint destruction. These enzymes are metal‐dependent, and inhibited by EDTA. EDTA was administered intraarticularly to rabbits in an experimental model of osteoarthritis. There was a 25% reduction in neutral proteoglycanase activity and 75% of the animals had a reduction in the severity of the arthritis as measured on a histologic‐histochemical grading system. It is suggested that future chemotherapeutic studies on arthritis might focus on enzyme inhibition.